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The Panel recommends against the use of baricitinib in the absence of remdesivir, except in a clinical trial (AIII). There are insufficient data for the Panel to recommend either for or against the use of baricitinib in combination with corticosteroids for the treatment of COVID-19. Since both agents are potent immunosuppressants, there is potential for an additive risk of infection. More data are needed to clarify the role of baricitinib in the management of COVID-19. Health care providers are encouraged to discuss participation in baricitinib clinical trials with their patients. December 3, 2020 Therapeutic Management of Patients with COVID-19 This section has been revised to include an Executive Summary with a more detailed discussion of the processes that are thought to drive the pathogenesis of COVID-19. These processes suggest that the effect of antiviral therapies will be greatest early in the course of COVID-19, whereas immunosuppressive/anti-inflammatory therapies are likely to have their greatest effect later in the course of the disease.